HORDB

ID: hor005854
Uniprot ID: Q25413
Protein name: QIPMLRL-amide
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: NA
Source: animal
Expression: Expressed in all ganglia of the CNS, but only in a subset of neurons.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: QIPMLRL
Length: 7
Propeptide: MQGAFLITFIVLTMTLVSIGNTEESGGQTSSNDKTEPAQSRTKRRSREMGRVVRGLQMLRLGKRDSVSTSEDPGDIDDILSLLQAYQEQNPEFAFNEEERELSGDELEVPEHHRFRRSTENSGVAPQEVQQSQSFKDSGEHELKLEEAEPYLYFPDGDFYYGDVDELLEGDNEDGSADKRQIPMLRLGKRSMSMLRLGKREEDDADFDEEKRSLSMLRLGKREDDNFEDSFDEENDKRSLSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKRPMSMLRLGKREDDEEKRSLAMS
Signal peptide: MQGAFLITFIVLTMTLVSIGNT
Modification: T7 Leucine amide
Glycosylation: NA
Mutagenesis: NA

Function: Myomodulins enhance the relaxation rate of electrically-induced contraction of the penis retractor muscle.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005854_AF2.pdb

hor005854_ESM.pdb

Mass:	97733	Formula:	C39H71N11O9S
Absent amino acids:	ACDEFGHKNSTVWY	Common amino acids:	L
pI:	10.55	Basic residues:	1
Polar residues:	0	Hydrophobic residues:	3
Hydrophobicity:	62.86	Boman Index:	-335
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	167.14
Instability Index:	2120	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 8756426
Title: Myomodulin gene of Lymnaea: structure, expression, and analysis of neuropeptides.
PubMed ID: 7808235
Title: Structural identification, neuronal synthesis, and role in male copulation of myomodulin-A of Lymnaea: a study involving direct peptide profiling of nervous tissue by mass spectrometry.
PubMed ID: 8522970
Title: Various isoforms of myomodulin identified from the male copulatory organ of Lymnaea show overlapping yet distinct modulatory effects on the penis muscle.